POE2: Slithering Dead Quest Guide

This guide details the Path of Exile 2 (PoE 2) side quest, "The Slithering Dead," including a walkthrough and a comprehensive analysis of the reward choices.

Quick Links

• The Slithering Dead Quest Walkthrough
• Choosing Your Venom Draught Reward

The Slithering Dead Quest Walkthrough

This side quest, initiated by Servi in the Ziggurat Encampment, involves uncovering the secrets of a rival tribe and the fate of her son. The quest is relatively simple once you locate the Venom Crypts.

To begin, enter the Jungle Ruins map in Act 3 (and Act 3 Cruel) and find the Venom Crypts entrance near the Waypoint. The Venom Crypts are separate from the main questline (Legacy of the Vaal) and can be revisited later if missed.

Explore the Venom Crypts until you find a corpse in the Den of the Serpent Priestess (location varies due to map randomization).

Interact with the corpse to obtain Corpse-Snake Venom. Return to Servi in the Ziggurat Encampment and give her the venom to complete the quest.

Choosing Your Venom Draught Reward

The Slithering Dead is a repeatable quest (Act 3 and Act 3 Cruel). The rewards, Venom Draughts, are unique to each act and the choice is permanent.

Act 3 Reward Choices

Servi offers three Venom Draughts:

Recommendation: Venom Draught of Clarity is generally the best option, especially for melee builds lacking mana regeneration. Venom Draught of the Veil is a strong alternative for builds less reliant on mana. Venom Draught of Stone is the least desirable unless specifically needed to mitigate stun effects.

Act 3 Cruel (Act 6) Reward Choices

The Act 3 Cruel rewards are:

Recommendation: Venom Draught of the Lost (+10% Chaos Resistance) is superior for most builds due to the rarity of Chaos Resistance on gear. Only builds utilizing Chaos Inoculation and Eternal Youth should consider Venom Draught of the Sky.

Remember, your choice is final! Carefully consider your build and its needs before selecting your Venom Draught.